In addition, we observed similar allele frequency of rs1131636‐T between NPC cohorts and Eastern Asian populations with close geography and ancestry; and interestingly, the highest and lowest frequencies are observed in the European and African/South Asian populations, respectively, which might suggest the allelic heterogeneity and various linkage disequilibrium structures in RPA1 locus among the populations (Table S4, Supporting Information). The gene discussed is RPA1; the disease is nasopharyngeal carcinoma.