This is consistent with a very recent finding in another NPC cell line,[24] as well as the finding in esophageal cancer.[25] The correlation of RPA1 to the genes involved in crucial DNA repair pathways as revealed by transcriptome analysis would suggest that NPC tumors with higher expression or activation of RPA1 might result in a higher repair fidelity of radiation‐induced DNA damage leading to radioresistance.[26] Next, we identified that miR‐1253 can target the seeding region spanning rs1131636 at the 3′‐UTR of RPA1, which suppresses the protein expression of RPA1, but not transcription. The gene discussed is RPA1; the disease is esophageal cancer.