NFAT activation is involved in TNFα release,[67] known to target tumor apoptosis in a T‐cell dependent manner.[67, 68] Like with the other two transcription factors investigated, however, NFAT was also previously linked to immunosuppressive effects,[69] making tissue–environmental factors likely to tip the balance of these pathways toward either tumor promotion or tumor regression.[70]. This evidence concerns the gene TNF and neoplasm.