Embryonic stem cells derived small extracellular vesicles (ESC‐sEVs) can rejuvenate H‐NSCs senescence by transferring miRNAs including miR‐17‐5p, miR‐18a‐5p, miR‐21‐5p, miR‐29a‐3p, and let‐7a‐5p to inhibit mTORC1 activation, and promote transcription factor EB nuclear translocation and lysosome resumption, which reverses senescence‐related neurogenesis dysfunction and cognitive impairment in VD. This evidence concerns the gene TFEB and sexually transmitted disease.