Among the 38 potential SRSP‐interacting splicing regulators, the interaction with SRSF3 was particularly interesting and was selected for further investigation because SRSF3 is a major splicing factor in AS and has critical roles in the regulation of the premRNA splicing, and dysregulation of SRSF3 contributes to tumorigenesis and progression of several human cancers.[12, 13] We further confirmed that SRSP could interact with SRSF3 (Figure 4C). This evidence concerns the gene PPP3CA-DT and cancer.