The unique cell surface markers expressed by TME‐associated cells represent an enticing direction to pursue and can likewise serve to achieve targeted delivery.[105] In one study, the expression of intracellular migration inhibitory factor from macrophages was effectively inhibited by the injection of siRNA‐loaded glucan NPs, resulting in CD4+ and CD8+ cell expansion at tumor sites and the promotion of anti‐tumor immunity, by inducing inflammatory cytokines such as tumor necrosis factor‐α (TNF‐α) and IL‐2.[116]. This evidence concerns the gene IL2 and neoplasm.