In 2011, Mavrakis and colleagues studied 50 clinical samples and 18 T-ALL cell lines and found out that miR-20a, miR-92, miR-26a, miR-223, and miR-19b had been increased in T-ALL and subsequently suppressed several tumor suppressor genes including IKAROS, PTEN, BIM, PHF6, NF1, and FBXW7. These miRNAs were able to induce leukemia in mice within 75 days (31). This evidence concerns the gene NF1 and acute lymphoblastic leukemia.