PTEN and acute lymphoblastic leukemia: In 2011, Mavrakis and colleagues studied 50 clinical samples and 18 T-ALL cell lines and found out that miR-20a, miR-92, miR-26a, miR-223, and miR-19b had been increased in T-ALL and subsequently suppressed several tumor suppressor genes including IKAROS, PTEN, BIM, PHF6, NF1, and FBXW7. These miRNAs were able to induce leukemia in mice within 75 days (31).