On the other hand, icotinib, as an effective and specific EGFR-TKI, especially for EGFR-mutant NSCLC, is fat-soluble and safe, and it can easily cross the blood-brain barrier or cell membrane, thus having positive antitumor effects in the clinical treatment of NSCLC (13). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.