Furthermore, IL-23, a heterodimeric cytokine formed by pairing of IL-23p19 and IL-12/23p40 subunits, which is secreted by DCs, is essential to the development of pathogenic Th17 cell responses and autoimmune diseases, such as EAE and rheumatoid arthritis diseases (13, 14). The gene discussed is IL23A; the disease is autoimmune disease.