STAT3 and cancer: For instance, chr 1:167407858 - C/T encoding the CD3Z p.Y83* variant deletes ITAM motifs (cancer cohort, MAF ~ 4%), chr 15:41799439 - AGG/A encoding the Leukocyte tyrosine kinase receptor (LTK) p.PE465* variant deletes ITIM motifs (Wellderly cohort, MAF ~ 50%) whereas rs746741787 - CAG/TCCAG encoding the fms-like tyrosine kinase 3 (FLT3) p.I638* truncation variant leaves intact the two STAT3 recruiting TBSMs namely namely ‘566-YKKQ’ and ‘572-YESQ’ while deleting the cytoplasmic domain (Fig. 1D–F).