ART4 and primary central nervous system lymphoma: While, PPI networks showed potential hubs for immune system, oxidative phosphorylation, cytoskeleton, and ribosomal protein in both HKBML-MTX and TK-MTX, mitochondria respiratory chain, glycosylation, and cell proliferation in HKBML-MTX, and proteasome, ATP synthesis, and glycoprotein in TK-MTX, suggestive of target therapies corresponding to PCNSL cell-types.