Thereby, the following potential markers for prognoses in PCNSL were isolated: FOXD2-AS1, MMP19, FABP5, CD70, CLCN2, HOXB9, INE1, LRP5L, CSAD, MYLK-AS1, ZNF169, DHDH, and IMPA2. In addition, NRL, PRPF40B, RASGRP2, RUNX1, SMG1P1, TOP3B, TRIM66, and ULK1 were also identified as prognostic marker candidates. The gene discussed is ZNF169; the disease is primary central nervous system lymphoma.