Thereby, the following potential markers for prognoses in PCNSL were isolated: FOXD2-AS1, MMP19, FABP5, CD70, CLCN2, HOXB9, INE1, LRP5L, CSAD, MYLK-AS1, ZNF169, DHDH, and IMPA2. In addition, NRL, PRPF40B, RASGRP2, RUNX1, SMG1P1, TOP3B, TRIM66, and ULK1 were also identified as prognostic marker candidates. This evidence concerns the gene DHDH and primary central nervous system lymphoma.