Chorea-acanthocytosis (ChAc) is a rare hereditary disease caused by loss-of-function-mutations of the chorein encoding gene VPS13A (vacuolar protein sorting-associated protein 13A)7,13, leading to progressive autosomal recessive neurodegenerative disease characterized by severe pleotropic movement disorders, epilepsy, decline of cognitive functions, and variable erythrocyte acanthocytosis4,7,11,14–22. This evidence concerns the gene VPS13A and epilepsy.