COMMD1 and cancer: The COMMD family of proteins presents as promising prognostic and therapeutic targets for the treatment of cancer.15,16 COMMD proteins contain a characteristic COMM domain within their C-terminus, which provides a platform for protein interactions.16 The expression of COMMD1 and COMMD9 have previously been studied in lung cancers.14,20 In this study, we examined the role of COMMD4 in NSCLC.