The COMMD family of proteins presents as promising prognostic and therapeutic targets for the treatment of cancer.15,16 COMMD proteins contain a characteristic COMM domain within their C-terminus, which provides a platform for protein interactions.16 The expression of COMMD1 and COMMD9 have previously been studied in lung cancers.14,20 In this study, we examined the role of COMMD4 in NSCLC. The gene discussed is COMMD4; the disease is lung cancer.