As genomic instability is a hallmark of all cancers53 and COMMD4 transcript and protein levels are upregulated in NSCLC, targeting COMMD4 as a therapeutic target in NSCLC may lead to uncontrolled chromatin remodelling, ultimately resulting in mitotic catastrophe-induced apoptosis in these cells. The gene discussed is COMMD4; the disease is non-small cell lung carcinoma.