Radiotherapy in early-stage NSCLC (stage I and II) has traditionally been used in patients who are medically considered inoperable, while radiotherapy remains the standard option for stage IIIA and IIIB NSCLC patients.10,34,35 The induction of mitotic catastrophe has previously been linked to radiation sensitivity.26,36 As we found that COMMD4 depletion induced mitotic catastrophe in NSCLC, we next sought to explore the therapeutic potential for depleting COMMD4 to impact radiation sensitivity. This evidence concerns the gene COMMD4 and non-small cell lung carcinoma.