If NSCLC is diagnosed at early-stage, the 5-year survival can be as high as 90% with treatment options of surgery, radiation therapy, radiofrequency ablation and chemotherapy.7,49 However, at the time of diagnosis, 40% patients present at advanced stage and in metastatic NSCLC, the median survival can be as low as eight months.35,50 As radiotherapy and chemotherapy remain a frontline treatment for NSCLC,49 we examined the viability of NSCLC cells depleted of COMMD4 in combination with either irradiation or the DNA damaging agent, camptothecin. Here, COMMD4 is linked to non-small cell lung carcinoma.