Transfection of two independent siRNA sequences targeting COMMD4 showed significantly reduced proliferation of H460, H1975 and CRL5889 NSCLC cell lines compared to the HBEC3-KT cell line transfected with COMMD4 siRNA, suggesting that COMMD4 is required for the proliferation of these NSCLC cells. This evidence concerns the gene COMMD4 and non-small cell lung carcinoma.