Further bioinformatic analysis revealed that COMMD4 expression is significantly increased in both ADC and SCC subtypes, with the relative expression elevated in ADC (n = 515, p = 4.5 ×10−11) and SCC (n = 503, p < 2 × 10−16), compared to non-malignant tissue (Fig. 1c). The gene discussed is COMMD4; the disease is AIDS dementia complex.