Indeed, a novel Cu(II)-mal-picoline complex was shown to induce mitotic catastrophe and result in apoptosis in HeLa cells.52 Inducing mitotic catastrophe in cancer cells has proven to be a promising anti-cancer strategy.32 As COMMD4 transcript and protein levels are upregulated in NSCLC, targeting COMMD4 in NSCLC may provide a therapeutic window that specifically kills cancer cells. Here, COMMD4 is linked to non-small cell lung carcinoma.