In terms of adipocytes, it has been reported that CXCL2 secretion was highly elevated in differentiated adipocytes32 and obese human adipocytes.33 A recent study reported that born marrow adiposity induced bone-destruction bearing prostate cancer cells through increased secretion of CXCL1 and CXCL2.34 However, little is known about the potential roles of CXCL2 in adipocytes. Here, CXCL2 is linked to Familial prostate cancer.