The other study showed that omental adipocytes overexpressed salt-inducible kinase 2 in ovarian cancer cells, which induced cell proliferation and peritoneal metastasis thorough the PI3K-AKT pathway.19 The omental adipocyte-induced AKT phosphorylation was consistent with our results, which may be a key signal for omental adipocyte-induced cancer progression. This evidence concerns the gene SIK2 and cancer.