In terms of adipocytes, it has been reported that CXCL2 secretion was highly elevated in differentiated adipocytes32 and obese human adipocytes.33 A recent study reported that born marrow adiposity induced bone-destruction bearing prostate cancer cells through increased secretion of CXCL1 and CXCL2.34 However, little is known about the potential roles of CXCL2 in adipocytes. The gene discussed is CXCL2; the disease is prostate cancer.