Published research papers, clinical trials, and literature reviews were selected using different keywords (e.g., NF1, neurofibroma, malignant peripheral nerve sheath tumour, optic glioma) and database sources (e.g., PubMed, Google Scholar, ISI Proceedings, Journal storage [JSTOR] Search, Medline, Scopus, Web of Science, Clinicaltrials.gov). Here, NF1 is linked to malignant peripheral nerve sheath tumor.