NF2 and Vestibular schwannoma: As a central regulator of cell growth and size, it is not surprising that the Hippo pathway is involved in a number of tumour types, including NF2-associated tumours.68 The NF2 disease, characterised by highly penetrant tumours of the vestibular nerve called vestibular schwannomas, is caused by biallelic inactivation of the NF2 gene.