The results of a study in an autologous mouse model suggest that pregnancy might favour the development of cNF,87 while OPG-induced retinal ganglion loss and retinal nerve fibre layer thinning in mice were reported to depend on the presence of ovaries.88 In humans, female NF1 patients are reported to be at a higher risk than the general population of developing breast cancer.89 Results from several studies point to a correlation between the NF1 and oestrogen receptor status in multiple model systems. The gene discussed is NPHS1; the disease is neurofibromatosis type 1.