We are confident that the ODCs validated through our study are of high quality, as it has been demonstrated that a triple combination of AZD8055, pictilisib and selumetinib can reduce tumour growth in vitro as well as in vivo settings.66 The potency of the anticancer efficacy resulted from an underlying synergy between mTORC1/2 (AZD8055), PI3K (GDC-0941) and MEK1/2 (selumetinib) inhibitors.66 In accordance with these studies, we are confident that our approach revealed ODCs with highly selective and synergistic anticancer activity. The gene discussed is MAP2K1; the disease is neoplasm.