Several LncRNAs related to TMZ resistance were found, but LncRNA SOX2OT and its nearby gene, sex determining region Y-box 2 (SOX2), were of note because they were upregulated in TMZ-resistant cells, and previous studies demonstrated that SOX2OT participates in genesis of various malignant tumors by regulating different molecules18. This evidence concerns the gene SOX2-OT and cancer.