Further, the protein levels of IL-4, IL-6, TSLP, IL-17a, and IL-1b also were increased in the dorsal cutaneous tissue of mice in the DNCB-induced AD-like symptom group than those in the control group (Fig. 6f–j; p < 0.05), and topical CA-PH treatment significantly reduced the protein levels of IL-4, IL-6, TSLP, IL-17a, and IL-1b (p < 0.05). Here, IL4 is linked to Alzheimer disease.