Lastly, transplantation of human BCR-ABL1+ versus BCR-ABL1T315I+ CML cells into NSG mice treated in pairs with vehicle or fibronectin led to a nonsignificant reduction of the engraftment of human CD45+ leukocytes in the majority of treated versus untreated mouse pairs (Fig. 7l). The gene discussed is PTPRC; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.