Furthermore, fibronectin levels were significantly reduced in bone sections (P = 0.043; Fig. 7i, j) and levels of ILK, ILK pS246 and integrin β3 were higher in leukemia cell samples from most patients with BCR-ABL1T315I+ compared with BCR-ABL1+ CML, though inter-patient variability was observed (Figs. 7k and S8I). This evidence concerns the gene BCR and leukemia.