To compare lineage pathways in the tumor samples analyzed, we calculated and plotted z-scores to identify outlier genes for each lineage (color and boxes) including basal (Itga6, Cd44, and Col17a1), squamous (Tgm1), luminal (Gpx2 and Erbb2), EMT-claudin (Snail1, Snail2, Cldn7), Neuronal differentiation (Sox2 and Chga), Immune (Saa3), and luminal (Gpx2 and Upk2) shown together (Supplementary Fig. 11B) or as independent lineages (Supplementary Fig. 11C). The gene discussed is UPK2; the disease is neoplasm.