Human primary bladder tumors were assessed for positive immunostaining of basal (Ck5, p63), luminal (Ck8), and EMT-claudin (Cldns 4, 5, or 7) markers from which we identified tumor regions being basal only, luminal only, and mixed basal–luminal in composition. The gene discussed is KRT5; the disease is urinary bladder neoplasm.