As for the symptoms, PANSS scores were positively correlated with CSF HGF and S100B levels in patients with schizophrenia, while YMRS and HAMD-21 (including subscale) scores were positively correlated with CSF S100B levels in patients with BD and CSF HGF, S100B, and VEGF receptor 2 levels in patients with MDD, respectively. The gene discussed is S100B; the disease is schizophrenia.