Next, to test the role of sEH in DN, db/db mice and HK-2 cells were treated with the sEH pharmacological inhibitor t-AUCB, and we found that t-AUCB treatment partially preserved renal function of db/db mice and attenuated apoptosis of HK-2 cells exposed to HG. This evidence concerns the gene EPHX2 and liver dysplastic nodule.