WWTR1 and neoplasm: Second, SAV1 induces the protein kinase-phosphorylation cascade (MST1/2-LAST1/2-YAP/TAZ) in the Hippo pathway and simultaneously inhibits several other tumorigenic signal pathways, such as the AKT and NF-κB signal pathways in cancer cells, therefore amplifying SAV1-mediated tumor suppression.