PLK1 and cancer: Among these are: i) polo-like kinase 1 (PLK1), a member of the polo-like family of serine/threonine kinases that plays a crucial role in cell-cycle regulation during mitosis [27]; ii) Y-box-binding protein 1 (YBX1), a transcription and translation regulator protein that increase cancer cell invasiveness and spreading [28]; iii) the myeloid cell leukemia-1 protein (Mcl-1), an anti-apoptotic Bcl-2 family member [29].