The Early-Onset form of Alzheimer’s Disease (EOAD) is due to mutations in chromosome 21, causing the formation of abnormal amyloid protein (APP) [1], and mutations on chromosomes 14 and 1 leading to abnormal presenilins 1 and 2 which undergo cleavage of APP [2,3]. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.