CASP2 and neoplasm: More remarkably, genetic inhibition of caspase-2 by siRNA suppresses apoptosis of tumor cells induced by genotoxic insults such as etoposide, cisplatin, and 5-fluorouracil (5-FU) in tumor cells [7,120,147,166] and DNA enzyme (DZ13) induced caspase-2 activation has also been implicated in tumor suppression [122].