CASP2 and cancer: In support of this notion, Goniothalamin-induced oxidative stress, DNA damage, and apoptosis were shown to be caspase-2 and Bcl-2 in Jurkat T-cells [318], whereas 5-phenylselenyl- and 5-methylselenyl-methyl-2′-deoxyuridine-induced oxidative stress and DNA damage leading to apoptosis were caspase-2-dependent in cancer cells [122].