Consequently, downregulation of caspase-2L and upregulation of caspase-2S mRNA and levels of total caspase-2 mRNA expression has been implicated in tumor progression in vivo [31,162] and more importantly the nucleotide excision repair factor XPC has been shown to enhance DNA damage-induced cell death by downregulation of the antiapoptotic caspase-2S [33]. Here, CASP2 is linked to neoplasm.