NFKB1 and neoplasm: The anti-tumor function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mouse models, and these two residues are required for the inhibition of NF-κB activation, sustain the G2/M checkpoint and induce apoptosis, indicating combined functions of caspase-2 in the implication of its anti-tumorigenic function [180].