To investigate the relationship of the SIRT2 haplotypes (three SNPs combinations) with diabetes susceptibility, we established the risk estimation analysis and found that the individuals carrying haplotype combinations H1-H1-GGGGCC (OR = 2.03, 95% CI = 1.12–3.72, p = 0.02) displayed a significantly increased risk for T2D compared with H2-H2-CCCCAA (OR = 0.89, 95% CI = 0.51–3.24, p = 0.16) and H1-H4-GCGCCC (OR = 1.37, 95% CI = 0.69–3.91, p = 0.11) (Table 2). This evidence concerns the gene SIRT2 and diabetes mellitus.