The plasma glucose level of the T2D patients with H1-H1-GGGGCC was significantly higher than the ones carrying H2-H2-CCCCAA (p < 0.05), as well as showed a high trend comparing to H1-H2-GCGCCA or H1-H4-GCGCCC, while the most reduced insulin of the H1-H1-GGGGCC carriers were found due to the response towards the elevated plasma glucose contents at the 60 min or 120 min timepoint of the test. This evidence concerns the gene INS and type 2 diabetes mellitus.