Our data shows that the MAPK/ERK pathway is involved in APE1-mediated pancreatic cancer cell proliferation; therefore, two different methods were used to determine whether Src activation is necessary for APE1-mediated cell proliferation: knockdown of Src expression by siRNA specific for Src and inhibition of Src phosphorylated activation with the chemical inhibitor PP1. Here, APEX1 is linked to familial pancreatic carcinoma.