ACE and diabetes mellitus: Diabetes and hypertension share common pathways among them the sympathetic nervous system (SNS), the renin-angiotensin-aldosterone system (RAAS) including angiotensin-converting enzyme (ACE), oxidative stress, adipokines, insulin resistance (IR) (currently considered a prothrombotic state) and peroxisome proliferator-activated receptors (PPARs) [46].