BRCA2 and breast cancer: In fact, in our cohort, 24 BC patients (44%) carried BRCA1 variants falling into the BRCT domain while 16 OC patients (40%) showing variants in the OCCR and BRCT domains (Figure 3a); regarding BRCA2, 46 BC patients (70%) and 30 OC patients (71%) presented variants in the OCCR domain (Figure 3b).