Deleterious germline PV carriers in BRCA1 or BRCA2 have an elevated lifetime risk of developing breast and/or ovarian cancer, particularly 60–80% for breast cancer (BC) and 26–54% for BRCA1 and 10–23% for BRCA2 for ovarian cancer (OC) [5,6]. The gene discussed is BRCA2; the disease is breast cancer.