EZH2 and non-small cell lung carcinoma: Indeed, in NSCLC cell lines (95C, 95D, and YTMLC-90), Liu et al. demonstrated that RB1 and E2F1 are both regulated by HOTAIR5’ via the PRC2 (EZH2, SUZ12, and EED) complex and by HOTAIR3’ via the LSD1/ CoREST/ REST complex.