In NSCLC cell lines (PC-9 and A549), MALAT1 also decreases cleaved-PARP1, cleaved-CASP3, and upregulates phospho-STAT3 [171], which in turn upregulates MDR1 (ABCB1) and MRP1 (ABCC1) [182]. This evidence concerns the gene CASP3 and non-small cell lung carcinoma.