Moreover, in human NSCLC cell lines (A549), H19 may regulate metastasis through the modulation of cell proliferation and cell adhesion proteins, including MACC1, EGFR, β-catenin (CTNNB1), ERK1 (MAPK3) and ERK2 (MAPK1) [141]. This evidence concerns the gene MAPK1 and non-small cell lung carcinoma.