In NSCLC cell lines (PC-9 and A549), MALAT1 also decreases cleaved-PARP1, cleaved-CASP3, and upregulates phospho-STAT3 [171], which in turn upregulates MDR1 (ABCB1) and MRP1 (ABCC1) [182]. The gene discussed is ABCC1; the disease is non-small cell lung carcinoma.