Besides, in NSCLC tumor tissues and cell lines (A549, H661, and H460), MALAT1 can upregulate CXCL5, which in turn upregulates p-MAPK8 and down-regulates p-MAP2K1/2, p-MAPK3/1 proteins [176,183]. The gene discussed is MALAT1; the disease is non-small cell lung carcinoma.