ZEB1 and non-small cell lung carcinoma: Furthermore, in NSCLC cell lines (SPC-A1 and H1299) in vitro and in vivo, TFAP2C and ZEB1 can upregulate MALAT1 expression, leading to the sequestration of miR-200b, which, in turn, increases of E2F3 and ZEB1, creating, therefore, a positive feedback loop [181].