Moreover, in NSCLC tumor tissues and cell lines (A549, H1299, HCC827, and H358), SOX9 could activate MALAT1 expression by binding MALAT1 promoter on a specific site (5′-TCATTGTGT-3′), thus creating a positive feedback loop which dramatically increases MALAT1 downstream effects. This evidence concerns the gene MALAT1 and non-small cell lung carcinoma.