More generally, the HOX cluster-embedded lncRNAs (HOX-lncRNAs) plays a significant role in the regulation of their adjacent coding genes and several HOX-lncRNAs, including HOTTIP, HOXA11-AS, HOTAIRM1, HOXA-AS3, HOXA10-AS, HOTAIR, and HAGLR, which are dysregulated in lung cancer [218]. This evidence concerns the gene HOTAIR and lung cancer.