In fact, it seems that in AD mouse models, layer II pyramidal cells co-expressing Reelin in the entorhinal cortex are more sensitive to amyloid β-protein accumulation, leading to their cell death [30], which reduces RELN expression and transport to the hippocampus [33], thereby enhancing amyloid plaque formation [66] and cognitive deficits. Here, RELN is linked to Cognitive impairment.