Thus, taking into account our observations and these previous descriptions, we envision a scenario resembling a “degenerating loop” during AD progression, based on: (i) the progressive presence of different amyloid β-protein species during AD evolution, leading to (ii) cell death of subsets of Reelin-positive and -negative cells, and (iii) Reelin accumulation in amyloid plaques or corpora amylacea in the entorhinal, hippocampal, and other subcortical structures [62], and then returning again to the first step in this “degenerative loop”. The gene discussed is RELN; the disease is amyloidosis.