Several studies have been recently conducted on the anti-tumor activity of AST and the mechanisms involved, and have reported that AST prevents oxygen-mediated cytotoxicity, modulates tumor immunity, and induces intrinsic apoptosis by inhibiting phosphatidylinositide 3-kinases (PI3), protein kinase B (AKT), and mitogen-activated protein kinase (MAPK) signaling [21,22,23,24]. Here, WNK2 is linked to neoplasm.