In this model, after a first melanoma challenge in the presence of an EpCAM/CD3-bAb, endogenous EpCAM-specific antibodies were induced in a T and accessory cell-dependent manner and mice survived subsequent tumor challenges without repeated antibody treatment while use of bispecific F(ab’2) fragments lacking the Fc portion failed to induce memory formation [40]. Here, EPCAM is linked to neoplasm.