reuterias an adjunct for nonsurgical periodontal treatment in chronic periodontitis were studied by Ince et al.31They reported that the decrease in GCF/MMP-8 levels and increase in tissue inhibitor matrix metalloproteinase-1 (TIMP-1) levels were observed to be significant at 21 days (p< 0.05), in both group of patients, those treated with SRP only and those with SRP and probiotics. This evidence concerns the gene TIMP1 and periodontitis.