Negative loadings (most common in CBS, nfvPPA and mixed PPA) linked global cognitive impairment, apraxia, cortical sensory loss and language impairments with atrophy in the parietal cortex (atrophy components 7 and 8); bvFTD (R = 0.49, P = 0.02), nfvPPA (R = 0.79 P = 0.001) and CBS (R = 0.7, P = 0.001) most contributed to this canonical variate. The gene discussed is CBS; the disease is primary progressive aphasia.