This critical role of T-channels of cortical and NRT, but not thalamocortical neurons in experimental absence seizures is compatible with the gain-of-function mutations of the Cav3.2 subtype of T-channels reported in some children with absence seizures (Chen et al., 2003; Khosravani et al., 2004) and in GAERS rats (Talley et al., 2000; Powell et al., 2009; Cain et al., 2018), as this subtype of T-channels is expressed in cortical and NRT neurons but not in thalamocortical neurons (Fig. 5) (Talley et al., 1999). Here, CACNA1H is linked to Generalized non-motor (absence) seizure.