A recent study on STXBP1, a gene encoding the presynaptic protein Munc18-1, shows that injection of muscimol in the striatum of Stxbp1−/− mice blocks their short (0.5–2 s) ethosuximide-sensitive absence seizures (Miyamoto et al., 2019). This evidence concerns the gene STXBP1 and Generalized non-motor (absence) seizure.