Notably, selective inhibition by DREADDS of cortical parvalbumin-positive interneurons has been shown to elicit absence-like seizures in normal mice (Panthi and Leitch, 2019) and genetic ablation of Cav2.1 channels in both parvalbumin- and somatostatin-positive cortical interneurons elicit severe generalized seizures and absence seizures (Rossignol et al., 2013). This evidence concerns the gene SST and Generalized non-motor (absence) seizure.