Notably, selective inhibition by DREADDS of cortical parvalbumin-positive interneurons has been shown to elicit absence-like seizures in normal mice (Panthi and Leitch, 2019) and genetic ablation of Cav2.1 channels in both parvalbumin- and somatostatin-positive cortical interneurons elicit severe generalized seizures and absence seizures (Rossignol et al., 2013). The gene discussed is SST; the disease is juvenile absence epilepsy.