The combined ORs were 0.89 (95%CI: 0.47∼1.68, Ρ=0.722) forCry1 and differentiation, 0.86 (95%CI: 0.22∼3.26, Ρ=0.825) for Cry1 and invasion depth and 0.55 (95%CI: 0.29∼1.03, Ρ=0.062) for Cry1 and lymph node metastasis. Here, CRY1 is linked to metastatic malignant neoplasm in the lymph nodes.