SPARCL1 and colorectal carcinoma: Human SPARCL1 expression is also commonly downregulated in other cancer tissues, including CRC, metastatic prostate adenocarcinoma [8, 9], non-small cell lung cancer [10], metastases of pancreatic cancer [11], gastric cancer [12, 13], breast cancer [14], and hilar cholangiocarcinoma [15].