LPL and hyperlipidemia: In the future, it would be of interest to examine the response of the PI3K-Akt pathway using lipoproteins, and the FFA component liberated by LPL, from subjects with controlled and uncontrolled hyperlipidemia; samples from such subjects might exhibit unique lipoprotein lipidomes that may impair cholesterol efflux in response to LPL hydrolysis, in addition to harboring high-density lipoproteins with poor cholesterol efflux capacity.