FLG2 and Alzheimer disease: The protein levels of FLG2 are also decreased in the SC and epidermis of AD patients [22, 23], in the SC from dandruff condition [9], in a lipid raft disruption model [24] and in ichthyosis peeling skin [19, 25] suggesting that FLG2 plays an important role in epidermal homeostasis and barrier formation.