Furthermore, the cleavage of GSDME but not GSDMD was observed in the BIX + Cis combined treated group and the KO of GSDME significantly switched pyroptosis to apoptosis, which confirmed that BIX combined Cis induced pyroptosis in gastric cancer dependent on the cleavage of GSDME and caspase‐3. The gene discussed is GSDMD; the disease is gastric cancer.