Gene involved in ‘regulation of inflammatory response’ (Adora1, C6, Ier3, Ighg1, Il1b, Il1r2, Itga2, Lbp, Nlrp12, S100a8, S100a9, Sema7a, Serpine1, Slamf8, Slpi, Socs3, Tnf, Tnfaip6, Tnfrsf11a, Tslp), ‘chronic inflammatory response’ (Ccl2, Il1b, Orm1, S100a8, S100a9, Thbs1, Tnf), and ‘acute inflammatory response’ (Adora1, C6, Hp, Ighg1, Il1b, Itih4, Lbp, Orm1, S100a8, Tnf, Tnfrsf11a) were significantly up-regulated in heat stroke lung (Figure 7). This evidence concerns the gene SERPINE1 and Heat Stroke.