Gene involved in ‘regulation of inflammatory response’ (Adora1, C6, Ier3, Ighg1, Il1b, Il1r2, Itga2, Lbp, Nlrp12, S100a8, S100a9, Sema7a, Serpine1, Slamf8, Slpi, Socs3, Tnf, Tnfaip6, Tnfrsf11a, Tslp), ‘chronic inflammatory response’ (Ccl2, Il1b, Orm1, S100a8, S100a9, Thbs1, Tnf), and ‘acute inflammatory response’ (Adora1, C6, Hp, Ighg1, Il1b, Itih4, Lbp, Orm1, S100a8, Tnf, Tnfrsf11a) were significantly up-regulated in heat stroke lung (Figure 7). Here, SOCS3 is linked to Heat Stroke.