Gene involved in ‘regulation of inflammatory response’ (Adora1, C6, Ier3, Ighg1, Il1b, Il1r2, Itga2, Lbp, Nlrp12, S100a8, S100a9, Sema7a, Serpine1, Slamf8, Slpi, Socs3, Tnf, Tnfaip6, Tnfrsf11a, Tslp), ‘chronic inflammatory response’ (Ccl2, Il1b, Orm1, S100a8, S100a9, Thbs1, Tnf), and ‘acute inflammatory response’ (Adora1, C6, Hp, Ighg1, Il1b, Itih4, Lbp, Orm1, S100a8, Tnf, Tnfrsf11a) were significantly up-regulated in heat stroke lung (Figure 7). The gene discussed is IL1B; the disease is Heat Stroke.