KMT2A knockdown by its specific shRNAs (sh1 and sh2) dramatically inhibited the expression of KMT2A protein in SiHa and Caski cells (Figure 1A), and significantly suppressed cell viability (Figure 1B, 1C) and resulted in a marked reduction in the number of the colony in cervical cancer cells (Figure 1D, 1E). This evidence concerns the gene KMT2A and cervical carcinoma.