In addition, overexpression of miR‐141–3p could inhibit hypoxia‐induced cell migration and impede human BC MDA‐MB‐231 cell growth in vivo. Mechanistically, hypoxia‐related HMGB1/HIF‐1α signaling pathway might be a potential target of miR‐141–3p to prevent the progression of BC. The gene discussed is HIF1A; the disease is breast cancer.