Co‐expression of miR‐605‐3p and TRAF6 largely reversed the tumour‐suppressive effects of miR‐605‐3p up‐regulation alone, which suggests that miR‐605‐3p inhibits the malignant behaviour of HCC cells by suppressing TRAF6 expression. The gene discussed is TRAF6; the disease is hepatocellular carcinoma.