Multivariate analysis included all parameters that showed a significant result in the univariate testing: age at primary breast surgery (P < 0.001), tumor size (P = 0.014), nodal status (P < 0.001), histological grade (P < 0.001), Ki-67 (P < 0.001) and molecular subtype (P < 0.001) [21]. This evidence concerns the gene MKI67 and neoplasm.