For example, fibrillar α-syn polymorphisms underlies different propagation patterns of α-syn pathology [49], while α-synuclein in glial cytoplasmic inclusions (GCI-α-Syn) forms more compact and about 1,000-fold more potent structures than Lewy bodies-α-Syn in seeding α-Syn aggregation, consistent with the highly aggressive MSA [50]. Here, SNCA is linked to multiple system atrophy.