INS and type 2 diabetes mellitus: Confirmation of long-term alpha-mangostin supplementation in type 2 diabetic rats was provided by Mekseepralard et al. (35) Alpha-mangostin given at 200 mg/kg BW/day for 40 weeks resulted in a decreased level of HbA1c, plasma cholesterol, fasting blood glucose, triglyceride, and followed by the increase serum insulin.