The six known integral membrane protein disorders are Danon disease lysosomal associated membrane protein-2 (LAMP2), sialic acid storage disease (SLC17A5), mucolipidosis IV (MCOLN1), Niemann-Pick disease type C1 and C2 (NPC1 and NPC2), cystinosis (CTNS), and action myoclonus-renal failure (AMRF) syndrome (SCARB2; Platt et al., 2018). The gene discussed is LAMP2; the disease is Niemann-Pick disease type C.