PRKN and Parkinson disease: While the generation of Parkin and PINK1 mutant flies has elucidated the functions of these genes in regulating mitochondrial integrity (Clark et al., 2006; Park et al., 2006; Palikaras et al., 2018), PINK1 and Parkin knockout mouse models poorly recapitulate dopamine neurodegeneration and the pathophysiology of human PD (Goldberg et al., 2003; Itier et al., 2003; Kitada et al., 2007; Billia et al., 2011; Hasson et al., 2013; Lazarou et al., 2015; Sliter et al., 2018).