PRKN and myocardial infarction: Mice with Parkin deletion demonstrate normal baseline cardiac phenotypes (Kubli et al., 2013; Piquereau et al., 2013), but exhibit an increased sensitivity to stress conditions from myocardial infarction (MI) or cardiac aging, along with a decline in cardiac mitophagy and accumulation of dysfunctional mitochondria (Hoshino et al., 2013; Kubli et al., 2013).