Although the etiology of AD remains unclear, the accumulation of intracellular hyperphosphorylated tau (p-tau) and extracellular amyloid β-peptide (Aβ) have been identified in the onset and progression of the disease (Braak and Braak, 1995; Fivenson et al., 2017; Fang et al., 2019; Thal et al., 2019). Here, MAPT is linked to Alzheimer disease.