PRKN and Parkinson disease: The products of two PD-associated genes, the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and the cytosolic E3 ligase Parkin, can sense mitochondrial damage and mediate ubiquitin-dependent mitophagy (Narendra et al., 2008; Youle and Narendra, 2011; Pickrell and Youle, 2015; Yamano et al., 2016; Palikaras et al., 2018).