Specifically, mutations or variants of PINK1 and Parkin have been found in the inherited forms of early-onset PD’s patient (Kitada et al., 1998; Valente et al., 2004; Lazarou et al., 2015; Bingol and Sheng, 2016; Sliter et al., 2018). This evidence concerns the gene PRKN and Parkinson disease.